AmaZulu take on SuperSport United in their third DStv Premiership clash of the season at the Jonsson Kings Park Stadium on Tuesday.
The Benni McCarthy-managed outfit are one of three teams yet to register a win this season, and sit second-bottom on the table with one point from two matches.
Usuthu also started their maiden CAF Champions League campaign on Friday with a 1-0 loss to ten-man Nyasa Big Bullets in the preliminary round first-leg at home.
On the other hand, Matsatsantsa are high in confidence after getting their first victory of the campaign at home to Golden Arrows and will look for their first away win of the term.
With a fourth-place standing currently, Matsatsantsa can go level on seven points with rivals Mamelodi Sundowns at the top of the pile with a victory.
SuperSport were on the losing end in this fixture near the end of last season, but will draw confidence from their recent victory to overcome Usuthu this time around.
AmaZulu: Mothwa, Moleko, Mzava, Xoki, Malepe, Sithebe, Buchanan, Makhaula, Qalinge, Moremi, Mthembu.
Subs: Amonome, Gumede, Mgwazela, Mlambo, Maduna, Ektsein, Memela, Majoro, Ntuli.
SuperSport: Williams, Nhlapo, Fleurs, Ditlhokwe, Bhasera, Webber, Donn, Mokoena, Mahachi, Grobler, Rayners.
Subs: Chigova, Philipps, Mkhwanazi, Mbatha, Waiswa, Moralo, Appollis, Manziba, Gabuza.